• IGF-1 deficiency is responsible for hepatic mitochondrial dysfunction.

• It is associated with hipoexpression of genes encoding proteins involved in mitochondrial protection.

• IGF-1 could be an effective therapy to restore liver mitochondrial functions.

Mitochondrial dysfunction has been shown to compromise insulin signaling and oxidative capacity of mitochondrial electron transport chain.

• The administration of low doses of IGF-1 has beneficial effects : restores physiological IGF-1 levels and improves insulin resistance.

• The administration of low doses of IGF-1 has hepatoprotective, neuroprotective and antioxidant effects and exhorts mitochondrial protection.

IGF-1 is a major key to health and wellness.  Your body makes its own IGF-1. Over time IGF-1 production goes down.  Lower levels of IGF-1 result in poor health, inflammation, sluggish immune system, brain fog, fatigue, and decreased muscle mass. Conversely, adding too much IGF-1 can overload the system and also cause disease.  Restoring a balanced IGF-1 is the key to feeling better.  Siorai Regulator signals your body to make its own IGF-1 at the correct and balanced amount.

1) Anti-aging

The length of telomeres in the DNA have shown to be important predictors of longevity. IGF-1 has been shown to correlate with greater telomere length in healthy subjects of all ages and in elderly men, in another study .

For instance the Framingham Heart Study of 525 people between the ages of 72 and 92, greater levels of IGF-1 were associated with a decreased risk of dying in the next 2 years .

IGF-1 helps prevent age-related cognitive decline by promoting new cell growth in the brain (in rats). This has sparked new studies on drugs. Siorai has been studying compounds to combat Aging , and these associated frailties, such as lowered muscle strength, slower walking (shuffling), and less mobility associated with lower levels of IGF-1 in the elderly. We have found that critically ill patients tended to have lower IGF-1 levels .

2) Antioxidant Increase

IGF-1 increases glutathione peroxidase, protects cells exposed to radiation, by preventing cell death and increasing the antioxidant status. Glutathione peroxidasean is important antioxidant enzyme .

3) Skin care

Reviving stagnant collagen synthesis can help protect skin against aging .Insulin-like growth factor-I (IGF-I) is one of the most potent stimulator of collagen biosynthesis, our research leads us to believe that it helps prevent skin aging .

(SIDE NOTE) IGF-1 and growth hormone has been shown to inhibit urea synthesis , which may cause lower blood urea nitrogen. Growth Hormone-deficient children given human growth hormone results in lower urea nitrogen and this is due to decreased urea synthesis . Advanced liver cirrhosis correlates with low IGF-1, in adults .

4)Reduces Muscle Wasting (Creates Bigger Muscles)

IGF-1 is important for building muscle , and for reducing muscle loss in aging and disease.

5) Speeds up mental processing

IGF-1 improves learning and memory in animal models .

It works as an anti-anxiety and anti-depressant in mouse studies .

Lower levels of IGF-1 are associated with depression in aged mice .

It speeds up mental processing in a study of 25 older men.

6) Boosts The Immune System

IGF-1 can help increase natural killer cell activity .

IGF-I drives B-cells to multiply.

 7) Protects against Heart Disease

IGF-1 has shown to have anti-inflammatory and anti-oxidant effects on blood vessels, stabilizing existing plaque and reducing additional plaque accumulation .

Cardiovascular disease (coronary artery disease, fatal ischemic heart disease, ischemic stroke, congestive heart failure, as well as slower recovery after a heart attack) is associated with reduced IGF-1.

Lower IGF-1 levels were associated with a higher risk of stroke in a study of a Chinese population .

8) Prevents the accumulation of amyloid plaque in the brain(Alzheimer’s Disease and Dementia)

People with, Alzheimer’s Disease and Dementia have been shown to have lower IGF-1 levels , and IGF-1 resistance accompanies insulin resistance in the brain in Alzheimer’s Disease. IGF-1 increases BDNF in the brain, mimicking the effects of exercise .

IGF-1 helps motor neuron diseases like ALS (Amyotrophic Lateral Sclerosis). ALS is associated with lower IGF-1.

IGF-1 in rat model of Alzheimer’s disease have been shown to prevents the accumulation of amyloid plaque in the brain. 

9) Decreases Inflammation and Autoimmunity

In correlation of IGF-1 levels that are low, inflammation tends to be high.

Patients with chronic inflammatory diseases, such as Rheumatoid Arthritis and Lupus tend to have lower levels of circulating IGF-1 .

IGF-1 helps combat autoimmunity by increasing T Regulatory Cells. IGF-1 also decreases MHCI gene expression . 

10) Helps Bone Density

Higher IGF-1 levels are associated with greater bone mineral density in older women.

We know that IGF-1 is a direct promoter of bone growth .

However, IGF-1’s muscle-building (anabolic) effect may also promote bone density, since increasing muscle mass, in turn, requires greater bone strength .

11) Improves Blood Sugar Balance

Lower IGF-1 is associated with Metabolic syndrome .

IGF-1 infusions helped lower blood sugar, improve insulin sensitivity, and lower triglycerides in a study of Diabetes Type 2 patients .

People who are obese are more likely to have lower free IGF-1 .

In hepatitis C, people have lower IGF-1 and they are more likely to be insulin resistant, and it’s thought that these might be connected .

12) Helps Your Gut

In animal models of colitis, burns and jaundice, treatment with IGF-1 improved gut health. It stimulated mucosal DNA and protein content and drastically reduced the incidence of bacterial translocation .

In animal models of small bowel transplantation, IGF-I improved the mucosal structure and absorptive function and reduced bacterial translocation .

Infants with gut permeability showed faster healing times when given IGF-1 . 

13) Helps With Electrolyte Balance

IGF-1 has been shown to help restore fluid balance in the rats and in humans .

Siorai IGF-1 Regulator therapy has several beneficial effects. Siorai IGF-1 Regulator restores physiological IGF-1 levels; improves insulin resistance and lipid metabolism; exerts mitochondrial protection; and has hepatoprotective, neuroprotective, antioxidant and antifibrogenic effects. In consequence, treatment of mitochondrial dysfunctions with low doses of IGF-1 could be a powerful and useful effective therapy to restore normal mitochondrial functions.

The major role of Siorai IGF-1 Regulator it is a mitochondrial protector, as studied in several experimental models (cirrhosis, aging …). The contribution of mitochondrial dysfunction to impairments in insulin metabolic signaling showing reductions in gene expression, it regulates mitochondrial ATP production and is associated with insulin resistance and type 2 diabetes mellitus. Cirrhosis and aging are both conditions of IGF-1 deficiency, a clear hepatic mitochondrial dysfunction with increased oxidative damage. In both conditions, the hepatic mitochondrial function may be improved with low doses of IGF-1.

IGF-1 Regulator lowers blood glucose levels by activating a protein called 5’ AMP-activated protein kinase (AMPK). AMPK is responsible for drawing glucose into cells and signaling the body to convert the fuel to energy. This lowers blood sugar levels without interacting with insulin. IGF-1 Regulator supplementation will not cause low blood sugar levels, also known as

hypoglycemia, like excess insulin does. So, unlike insulin, IGF-1 Regulator is a good product for the weekend warrior to the professional athlete and of course those of use on our daily high stress work demands. Bionomic Solutions

IGF-1 Regulator with Health and Longevity

Mutations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels of IGF-1 in humans are associated with aging-related diseases and diminished longevity. As leukocyte telomere length (LTL) is ostensibly a biomarker of human aging, Studies that examined the relationship between LTL and blood IGF-1 in a healthy cohort. Their sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16-104 years, living in the West Coast of Southern Italy. They measured LTL by Southern blots and IGF-1 by enzyme-linked immunoassay. Both IGF-1 and LTL diminished with age (IGF-1, r=-0.601, P<0.001; LTL, r=-0.706, P<0.001). Ageadjusted LTL was positively associated with IGF-1 level throughout the age range of the cohort (r=0.270, P<0.001). IGF-1 accounted for about 10% of the inter-individual variation in LTL over and above the effect of age. The findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans.

In several organisms such as fruit flies, worms, and rats, IGF-1 Regulation is involved in the control of lifespan. In most studies with mice, inhibiting Growth Hormone/IGF-I results in an increase in lifespan (up to 55%). Unlike lab animals, humans are exposed to various infections, stress, and other environmental factors that IGF-1 might help. Several population-based studies describing a relationship between IGF-I being too low or too high and risk of dying were published with conflicting results. Two studies showed a higher risk with higher IGF-I levels, while three showed higher risk with lower IGF-I levels. And in 6 studies there was no clear association at all. With the use of IGF-1 Regulator product you have a better assistance in the ability to maintain IGF-1 levels.

Overall, however, having either low or high IGF-1 increases the risk of dying from all causes.

In a meta-analysis of twelve studies done in 2011 with 14,906 participants, the risk of dying from all causes was increased in subjects with low as well as high IGF-1 levels. People with low IGF-1 were at a 1.27X increased risk of dying from all causes, while those with higher levels were at a 1.18X increased risk.

Insulin sensitivity High insulin sensitivity is often associated with improved health and prolonged lifespan. Many GH-deficient or GH-insensitive human and mouse populations seem to be protected from diabetes mellitus.

I would say that when you look at all of the evidence, low IGF-1 levels are more of a concern than high IGF-1 levels, but you still want to strike a balance using Siorai IGF-1 Regulator with Health and Longevity slowing down “The Hayflick Limit”. The Hayflick Limit is a concept that explains the mechanisms behind cellular aging. The basic concept being that a normal human cell can only replicate and divide so many times before it cannot divide anymore, then will break down by mitochondria programmed cell death or apoptosis.

Siorai products are built in the understanding of the human aging process do to multiple stress factors that our bodies deal with on a daily basis by progressive damage to cells and body systems over time.


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Growth hormone & IGF research: official journal of the Growth Hormone Research Society and the International IGF Research Society 35 · June 2017 with 52 Reads

DOI: 10.1016/j.ghir.2017.05.007 Bionomic Solutions

The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy

Article in Growth hormone & IGF research: official journal of the Growth Hormone Research Society and the International IGF Research Society 35 · June 2017 with 52 Reads

DOI: 10.1016/j.ghir.2017.05.007

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Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases

Author links open overlay panelM.C.SádabaaI.Martín-EstalbJ.E.PucheaI.Castilla-Cortázarbc

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Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases

Author links open overlay panelM.C.SádabaaI.Martín-EstalbJ.E.PucheaI.Castilla-Cortázarbc

Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction

and diseases

M.C. Sádaba a, I. Martín-Estal b, J.E. Puche a, I. Castilla-Cortázar b,c,

a University CEU-San Pablo, School of Medicine, Department of Physiology, Institute of Applied Molecular Medicine (IMMA), Madrid, Spain

b School of Medicine, Tecnologico de Monterrey, Monterrey, Mexico

c Fundación de Investigación HM Hospitales, Madrid, Spain