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Dr.Bill Andrews

“Aging can be controlled and stopped, a statement solidly grounded in good science, which makes it both verifiable and demonstrable” – Bill Andrews, Ph.D.

The discovery of the enzyme, Telomerase, has been touted as the biggest medical breakthrough since antibiotics.

Telomeres are the “end part” of our chromosomes. Every time our cells divide, our telomeres get a little shorter, and every time they shorten, our cells age. That’s the central cause of aging.

They shorten throughout our lifetime, and when they reach an average of about 5,000 nucleotides, our cells cannot divide any further (the Hayflick Limit), and we die of old age.

In a cell that expresses telomerase, telomeres are lengthened as soon as they shorten; it’s as though every time the “telomere clock” inside our cells ticks once, telomerase pushes the hands of the clock back one tick.

 

Clinical Trials at Abich Laboratories

Our clinical, medically run tests were performed at Abich Laboratories in Italy and carried out on 100 volunteers over a one month period with measurements and results took halfway at day 15. This testing is over and above any ‘recommended’ number of volunteers in order to prove, without a doubt, the efficacy of One Truth. One Truth is developed to make your skin younger.

How does Telomerase Activation work?

When it comes to Telomerase Activation no other company can offer you as effective a product as Siorai can. The science of telomeres has been around for decades, in fact, their discovery heralding a Nobel Prize back in 2009 and the discovery of the Hayflick limit (discovering that cells have a pre-destined, finite lifespan) happening 4 decades ago. In the scientific community, these discoveries are not new, but the technology is. And now that we have legit and scientifically sound methods of reversing age by lengthening the telomere mainstream media is carrying the message to the non-scientific community. People all over are beginning to ask ‘how can I lengthen my telomeres?’ and ‘where can I buy something that will reverse my cellular aging?

What is a Telomere?

Telomeres are the “end part” of our chromosomes – a long, repetitive sequence of DNA in our genome, so long that it can be stained and seen under a microscope. Every time our cells divide, our telomeres get a little shorter, and every time they shorten, our cells age. That’s the central cause of aging.

Aging is programmed; we age at a somewhat predictable and constant rate. Therefore,
 it stands to reason that humans must have 
 a “clock” ticking inside us – some kind of timing mechanism counting us down to self-destruction. Biologists (and before them, philosophers) have always reasoned that this may be the case, but at the time, no one could find the mechanism.

The telomere is that mechanism. It is the “clock” of aging that ticks inside every dividing cell of the human body, and in learning how to wind that clock backwards lays the cure for human aging.

SkinCare

We have 2 comprehensive ranges of skincare products. One specifically for age reversal using telomerase activation and the other for detox and bacterial control using our Bio-Active Carbon Complexes. Bio-Active Carbon Complexes also act as high oxygen carriers and boost the skins oxygen levels and condition cells to function more effectively.

 

THE END REPLICATION PROBLEM

 

When a cell divides, the genetic material inside that cell needs to be copied. This process
 is called DNA replication. The limitation on 
 cell division are rooted in the very nature of DNA replication. The enzymes that replicate a strand of DNA are unable to continue replicating all the way to the end, which causes the loss of some DNA.

As an analogy, think of a DNA strand as a
 long row of bricks, and of DNA replication as
 a bricklayer walking backward on top of a brick wall Laying a new layer on top of that row. When the end of the wall is reached, the bricklayer finds himself standing on top of the brick he’s supposed to replicate. Since he can’t put down a brick where his feet are, he steps back and falls off the wall—leaving the very end of the wall bare. As a result, the new copy of the wall is a bit shorter than the original.

Just like this brick wall was copied imperfectly, our DNA is unable to perfectly copy itself. When a strand is replicated, the new strand is shorter than the old strand. If we lost portions of the information encoded in our DNA every time it replicated, human life would be impossible. Our cells couldn’t even divide enough times to allow us to be born before they went haywire due to the missing information, failing to perform their basic functions.

This is one of the reasons the telomere is essential. Its long, repetitive sequences of DNA give us a “buffer” of genetic material that contains no (essential) information, so it can be safely consumed as part of the normal DNA replication process.

Most of the cells in our body are in a constant state of division. Every system in our body suffers damage and needs constant upkeep, and cell division is the body’s primary method of performing that upkeep. Many of our cells divide about yearly to keep our organs functioning. And with every division, the telomere shortens a little more, and a little more, until it becomes so short that any further division would start eating into our genetic information and mutations that can lead to cell death.

Telomeres, like all DNA, are made up of units called nucleotides, arranged like beads on
 a string.

In the human genetic code, all our genetic information is coded using four nucleotides: adenine, guanine, cytosine, 
 and thymine. The nucleotides in human telomeres are arranged in the repeating sequence TTAGGG (two thymine nucleotides, one adenine nucleotide, and three guanine nucleotides). This sequence is repeated thousands of times in tandem in every telomere. When we are first conceived, the telomeres in our single-cell embryos are approximately 15,000 nucleotides long. Our cells divide rapidly in the womb, and by the time we are born, our telomeres have decreased in length to approximately 10,000 nucleotides. They shorten throughout our lifetime, and when they reach an average of about 5,000 nucleotides, our cells cannot divide any further (the Hayflick Limit), and we die of old age.

ACTIVATING TELOMERASE SLOWS DOWN AND CAN REVERSE CELL AGING

Obviously, there must be a way for our bodies to re-lengthen telomeres. Otherwise, our sperm and egg cells would contain telomeres the same length as the rest of our cells, which would yield embryos that would be biologically as old as we are. Because so much cell division takes place in the womb, our children would then be born much older than us. Humanity could not continue to exist for more than a generation or two if this were the case.

However, our reproductive cells do not exhibit telomere shortening and show no signs of aging. They are our germ line – the same one that has been dividing since the beginning of life on this planet. And this germ line is, essentially, immortal.

The reason this line of cells is immortal is that our reproductive cells produce an enzyme called telomerase. Telomerase has one primary function: to act like an assembly line that adds nucleotides to the ends of our chromosomes, thereby lengthening our telomeres.

In a cell that expresses telomerase, telomeres are lengthened as soon as they shorten; it’s as though every time the “telomere clock” inside our cells ticks once, telomerase pushes the hands of the clock back one tick.

Telomerase works by filling the “gap” left by DNA replication. Returning to the analogy of the bricklayer that can’t lay the last brick on the brick wall, telomerase would be like an angel that flies in and puts the last brick in place.

So given these effects of telomerase, can we just take telomerase as a supplement or topically apply it to reverse the aging process and extend our lifespans?

Unfortunately, the answer is no: telomerase doesn’t work that way. It doesn’t survive human digestion, and ingested telomerase never enters the bloodstream. And even if it were introduced directly into the bloodstream, or applied directly to your skin, telomerase does not and cannot penetrate a cell membrane. It is produced, used, and consumed, all within a single cell. Beware of products claiming to have ‘telomerase’ in them. Even if the manufacturers had

sourced telomerase in some way (eg extracting it from reproductive cells of an animal that expresses telomerase in the same way as a human does) which in itself is highly unlikely – the telomerase could never penetrate into the cells, it is too large a molecule.

Fortunately, we don’t actually need to insert the telomerase into our cells—because the ability to make it is already there. That’s because the DNA in every one of our cells is identical: a skin cell, muscle cell, and liver cell all contain exactly the same genetic information. Thus, if the cells that create our sperm and egg cells contain the code for telomerase, every other cell must contain that code as well.

The reason that most of our cells don’t express telomerase is that the gene is repressed in
 them. There are one or more regions of DNA neighboring the telomerase gene that serve as binding sites for a protein, and if that protein is bound to them, telomerase will not be created by the cell.

However, it is possible to coax that repressor protein off its binding site with the use of a small-molecule like the Telomerase Activating Series that Aglet Labs produces, that binds to the repressor and prevents it from attaching to the DNA. If the protein cannot attach, repress and stop telomerase forming then these cells will produce telomerase just like our reproductive cells already do. With the appropriate molecule, we can topically turn telomerase on in every cell that we apply too, thus allowing them to divide as many times as necessary without error. Our topical telomerase activators re-lengthen telomeres and reverse aging at a cellular level. When your cells are younger they exhibit all the traits of a young cell again producing collagen, elastin and regulating melanocytes to avoid pigmentation problems

SO HOW DOES TELOMERASE ACTIVATING SKINCARE WORK?

Telomerase Activating Skincare products work on the skin and skin cells by inducing the cells natural ability to turn on telomerase enzymes.

100 Volunteers showed visible improvements to their wrinkles, pigmentation, and tone of their skin. All volunteers showed reversals of major signs of aging in as little as 2 weeks (measured clinically).

Our clinical, medically run tests were performed at Abich Laboratories in Italy and carried out on 100 volunteers, women aged between 35-65 years old, over a one month period with measurements and results taken halfway at day 15.

This testing is over and above any ‘recommended’ number of volunteers in order to prove, without a doubt, the efficacy of topical telomerase activation.

  • Skin Firmness improved by an average of 20.33%

  • Skin Elasticity improved by 8.33%.

  • Skin Smoothness improved by 12.53% on the forehead and

  • 9.63% in the eye area.

  • Forehead wrinkles decreased by 14.04% and

  • crows feet wrinkles decreased by 11.07%.

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