There are the Isaac Newtons and the Albert Einsteins of the world who get all the credit for their incredible minds.
There are also plenty of geniuses who don’t get the recognition they deserve for their accomplishments.
Let’s change that up and talk about Leonard Hayflick, the mastermind who discovered the telomere effect.
Born in 1928, Leonard Hayflick fostered a lot of advancements in our understanding of the way that human cells age.
He spent much of the twentieth and twenty-first centuries studying this process and has made huge strides doing so.
How He Started
At an early age, Leonard Hayflick became interested in chemistry and even built a lab in his Philadelphia basement as a pre-teen.
After high school, Hayflick studied at the University of Pennsylvania and graduated in 1951.
After college, he got a job at a research lab studying bacteriology while pursuing his Master’s degree.
Hayflick received a Master’s degree in medical microbiology in 1953. From the school, he won a fellowship to a Ph.D. program, in which he continued his research in the field.
Hayflick received a Ph.D. in medical microbiology and chemistry in 1956 from the University of Pennsylvania.
From there, he continued doing research in microbiology.
After receiving his doctoral degree, he became (and remains) a Professor of Anatomy at the UCSF School of Medicine.
He also helped develop and became the co-founder of the National Institute of Aging.
How did he get there? In his early 40s, Leonard disproved the belief that had been held for over 60 years that normal body cells are immortal.
He discovered there was a limit that normal human cells can only multiply a certain amount of times before stopping. This is now known as the Hayflick Limit.
While this is impressive, he didn’t have an easy time after his discovery.
While Hayflick is still educating medical students and contributing to the scientific community, there is a reason he is not a household name.
A lot of backlashes ensued after his discovery in the scientific community.
Disputes were coming left and right, and he received a lot of slander from his cohort. But that was the least of his worries.
An investigation was conducted on his research and conduct by James Schriver. Concluding his investigation, he placed damaging charges accusing Hayflick of profiting off selling cells that belonged to the government.
He accused him of distributing cells that may be contaminated with harmful bacteria. This conclusion came when all samples in the lab were not accounted for.
Stanford was alerted to the NIH investigation and began its own inquiry to take disciplinary action against Hayflick. This inevitably led to his resignation from the institute that he co-founded.
However, his discovery of the Hayflick Limit paved the way for a lot of progress in anti-aging and understanding of the human body. Let’s talk about that.
Hayflick and the Telomere Effect
The Hayflick Limit led to science’s ability to aid in the prevention of the telomere effect, which is important for limiting the aging process. But what is it?
What It Is
Telomeres are the compound structures at the end of chromosomes, which are the strands on the cell’s DNA. Telomeres act as protective caps for the chromosomes.
Some of your cells divide every second of your life. The process keeps you alive. The issue with the process is that each and every time that a cell divides, the compound becomes shorter.
With 242 billion cells in your body being produced a day, it is easy to understand how this effect can harm your body over time.
When these compounds become too short, they become inactive or die, making it a large factor in the aging process. This discovery has led to a better understanding of how to prevent aging through lifestyle or treatment.
Telomere testing began as early as the 1930s by Nobel Prize recipients Hermann Muller and Barbara McClintock when they had observed the structures on the end of the chromosomes.
However, the confirmation of their purpose and their degradation came much later.
After the Hayflick Limit was confirmed, a theory was born that these structures were the cause of the limit in cell division.
With the groundwork laid for understanding the limit, the effects of telemorase, when the division of cells ceases, was confirmed by Elizabeth Blackburn and Jack Szostak, who both received Nobel Prizes in 2009 for their work.
In essence, they were able to confirm the reason behind the Hayflick Limit.
This is now believed to be the primary cause of human aging and further work is leading to more effective methods of preventing the telomere effect.
Anti-aging is a nearly $200 billion industry worldwide. With more valuable research available because of the collective work of these scientists, the industry is only growing.
With scientists now understanding the telomere effect, they are researching how to prevent it and are coming up with promising results.
The process of telomere lengthening is being studied further and is leading to critical development on preventing the aging process.
The effects are already in place for many anti-aging products and techniques. The lengthening process is described as “turning back the internal clock” or resetting a lot of the damaging effects that come with aging.
Scientists at Stanford University have found a way to lengthen human telomeres by as much as 1,000 nucleotides.
This can turn back the internal clock in these cells by the equivalent of many years of human life.
This not only deals with the superficial issues of aging, but further development can lead to helping people with genetic dispositions for telomerase, and other diseases associated with aging.
While more research is underway for optimal performance of preventing aging, there has been a lot of progress.
Hayflick’s work was very effective in leading to new discoveries and understanding the telomere effect.
Now that we are understanding more of how aging works, start preventing it and keep those telomeres as long as you can!